A method for the copper-catalyzed amidation of aryl chlorides using concurrent tandem catalysis (CTC) has been developed using a multifunctional copper catalyst. The proposed CTC mechanism consists of an initial halide exchange step to form aryl iodides from less reactive aryl chloride substrates. As the aryl iodide intermediate is generated, it is consumed as the substrate in a subsequent amidation reaction to form a new C-N bond. This new method is similar to those previously reported for the copper-catalyzed hydrodehalogenation and cyanation reactions of aryl halides via CTC methodologies. The substrate scope for the amidation reaction and evidence that the reaction occurs through a CTC mechanism will be presented.

Microwave-assisted copper-catalyzed amidation of aryl chlorides via concurrent tandem catalysis

254th National Meeting (2017)

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