The high-index facets found on tetrahexahedral (24-sided), trisoctahedral (24-sided), and hexoctrahedral (48-sided), gold nanoparticles have been shown to exhibit unique characteristics ranging from catalytic function to inherent chirality. Past work studying specific high-index faceted metal surfaces and nanoparticles have shown to enhance the separation of chiral molecules over their low-index or spherical counterparts. This work further investigates the use of modified and unmodified chiral nanoparticles as adsorbent phases for enantioselective purification of chiral pharmaceuticals from the solution phase. Polarimetry, IR spectroscopy, and quartz crystal microbalance measurements have been used to study the extent of separation and degree of adsorption of chiral molecules onto the surface of these gold nanoparticles. Chiral propylene oxide and chiral proline have been shown to enantiospecifically interact with the chiral surfaces of Au nanoparticles modified with D- or L- Cysteine and penicillamine. The effects of temperature, wavelength, Au nanoparticle shape, and Au nanoparticle size were studied to optimize enantiospecific adsorption onto the chiral nanoparticles. We have shown that increasing temperature, decreasing wavelength, and increasing nanoparticle size result in better separation and larger polarimetric rotations.

Enantiomeric separation of chiral pharmaceuticals using chirally modified Au nanoparticles with high-index facets

254th National Meeting (2017)

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