We have developed a new class of metallo-supramolecular agents that bind strongly and preferentially to DNA and RNA Y-shaped junctions (3-way junctions; forks; bulges) in vitro and prevent DNA transactions. They are taken up readily into cells and localise rapidly in cell nuclei, where they interfere with the processing of DNA leading to cell cycle arrest followed by apoptosis, without inducing genotoxicity or mutagenicity. Excitingly some of these agents also show potent anti-viral activities.<br/>Beyond genomic nucleic acids, DNA can also be used to create interesting synthetic nanostructures. We now show that our cylinders can bind to these nanostructures, and the cylinders can modulate the nanostucture’s shape. The cellular uptake and activity of these nanostructure-cylinder composites will be described.

Metallo-supramolecular cylinders that bind unusual DNA and RNA structures: From DNA nanoscience to bio-activity

254th National Meeting (2017)

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