Direct functionalization of C–H bonds represents a powerful and valuable strategy in organic synthesis to access novel chemical space and to rapidly build structural complexity and diversity. This presentation will focus on the use of selective C–H zincation to achieve versatile functionalization of both sp2 and sp3 C–H bonds, such as amination, amidation, arylation, vinylation, borylation and silylation, as well as their applications in the synthesis of biologically important molecules.

Functionalization of sp2 and sp3 C–H bonds via deprotonative zincation

254th National Meeting (2017)

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