Alkene difunctionalization represents a direct and powerful strategy to transform simple and readily available olefins into richly functionalized skeletons that are valuable in the synthesis of functional material and biologically important compounds. Toward this, copper-catalyzed olefin amino difunctionalization have been developed for the rapid construction of diverse nitrogen-containing acyclic and cyclic skeletons, by using electrophilic amino precursors. Such electrophilic amination not only enables the direct installation of electronically rich amino group via alkene difunctionalization but also contributes to a new alkene activation pathway, presenting great potential to design novel amino difunctionalization of alkenes.<br/>

Copper-catalyzed amino difunctionalization of alkenes

254th National Meeting (2017)

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