The design of fluorescent lanthanide complexes is of interest due to their tunable photophysical properties. Time resolved fluorescence, sharp emission peaks, and long luminescent lifetimes allow for the application of these complexes as biological assays and imaging agents. Our prior studies involving macrocyclic cryptates resulted in water coordination due to unsymmetrical encapsulation of the lanthanide center, quenching fluorescence. In our efforts to create coordinatively saturated ligand systems for biological imaging applications, we have synthesized a mixed donor chelating ligand and explored its lanthanide coordination chemistry. This ligand has a multidentate acyclic structure consisting of both pyridine and phenol donor sets with promising coordination geometry. We will describe the synthesis, structure, and spectroscopic properties of these complexes as well as initial efforts in applying them towards biological imaging.

Lanthanide mixed donor complexes as potential bioimaging agents

254th National Meeting (2017)

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