Gold nanoparticles (Au NPs) are considered to be a powerful platform technology in nanotechnology and cancer therapy. Au NPs have been utilized extensively in targeting different epitopes over-expressed in various tissues due to their unique physicochemical and optical properties, as well as their ease of synthesis, functionalization and biocompatibility.<br/>               On the other hand, carbonic anhydrase IX (CA IX) is a membrane-bound protein that is overexpressed under hypoxic conditions on the surface of cancer cells, allowing them to maintain normal intracellular pH while acidifying the extracellular space around the tumor and to increasing tumor invasiveness.<br/>               We will present our recent results towards the development of gold nanoparticles functionalized with carbonic anhydrase inhibitors. We will present the synthesis, functionalization and biological testing of Au nanoparticles decorated with different carbonic anhydrase inhibitors and will reveal their ability to target and kill hypoxic tumors overexpressing CA IX. Correlations will be made between ligand type, density and the colloidal stability, internalization ability, and tumor killing.<br/>

Surface chemistry dictates the internalization and cytotoxicity of carbonic anhydrase inhibitor functionalized gold nanoparticles targeting hypoxic tumors

254th National Meeting (2017)

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