Mycobacterium tuberculosis has afflicted humans since the dawn of civilization and despite recent progress the epidemic shows little sign of slowing. This lecture will discuss recent advances in the development of new agents to treat tuberculosis as well as the tools involved in this process. Recent work in the non-human primate model of disease has advanced our understanding of the course of the disease and the impact of specific agents on chemotherapy. Non-invasive imaging modalities, particularly PET/CT using probes specific for both the host immune response and bacterial metabolism have provided important clues on rational strategies to shorten the current six month duration of chemotherapy.

New Strategies for an old foe

254th National Meeting (2017)

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