The past few decades have witnessed rapidly growing interest in the application of nanotechnology in biomedicine. A major focus in this field is the design and engineering of particles for targeted therapy and diagnostics, as particles can facilitate high payloads, prolong the circulation time and availability of drugs, improve drug targeting and solubility, and provide controlled-release of therapeutics into the bloodstream or targeted tissues. The nanoengineering of particles through templated assembly (e.g., through layer-by-layer assembly or metal-ligand complexation) has been used extensively to engineer a diverse array of particles for such applications. This presentation will discuss our research on the development of nanoengineered particles and their bio-nano interactions, focusing on challenges encountered from processing to fouling and scale-up. These studies are aimed at obtaining detailed knowledge of complex bio-nano interactions, which is fundamental for enabling the rational design of particles for biological applications. The emerging theme of “convergent science”—including topics such as translational alignment, bio-nano standards, and dark data—a theme that is key for increasing the impact of nanoengineered materials in bio–nano science and beyond, will also be discussed.

Engineering particles for bio–nano science and beyond

254th National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.