We demonstrate a magnetic resonance image-enhancing nanoparticle with the potential for use in multiple biomedical imaging and therapeutic applications. The nanoparticle contains internal Gadolinium ions for T1 imaging contrast, located between an inner core and outer Au layer, in a multilayered geometry. The proton relaxivity is enhanced through longer-range interactions with the protons outside the nanoparticle, a radical departure from the molecular chelates currently in use for MRI. This new geometry provides a very large relaxivity enhancement (r1~ 24 mM-1s-1) compared to conventional chelating agents (Gd-DOTA: r1~3 mM-1s-1) at high magnetic fields (4.7 Tesla). This MRI-enhancing nanoparticle geometry opens new opportunities for the development of multifunctional MRI-active nanoparticles for biomedical applications

Enhancing T1 magnetic resonance imaging contrast with internalized Gadolinium(III) in a multilayer nanoparticle

254th National Meeting (2017)

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