Glycosaminoglycans (GAGs) are anionic, polydisperse, linear polysaccharides that are often highly sulfated.  Many physiological processes and diseases are modulated through GAG-protein interactions including: blood coagulation, cell growth and differentiation, host defense, viral infection, lipid transport and metabolism, cell-to-cell and cell-to-matrix signaling, inflammation, Alzheimer’s disease and cancer.  Glycomics/interactome research is currently undergoing rapid development as a result of recent advances in technologies for glycan structural analysis and glycan-protein interactions.  Surface plasmon resonance (SPR) is a powerful biosensor technique used to measure biomolecular interactions in real-time and label-free ligands. SPR has been successfully used for quantitative measuring of GAGs/heparin-protein, and biological evaluation of glycotherapeutics (such as heparin and low molecular weight heparins) in our lab.  This presentation reports the application of SPR in GAGs/heparin glycomics/interactome study. <br/>

GAGs glycomics/interactome research using SPR

254th National Meeting (2017)

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