Graphene oxide (GO) can be used as a novel nanocarrier for controlled drug delivery owing to its high loading capacity of drugs with aromatic structures. We developed a GO-hybridized hyaluronic acid (HA)-based hydrogel for perivascular drug delivery. HA serves as a biodegradable macroscale polymeric scaffold, making the prepared GO nanocarriers localized and stable in different microenvironment. The nanocarrier was firstly synthesized by attaching senexin A (SNX), a kinase inhibitor and a possible anti-tumor drugs, to GO via strong π–π interaction, followed by in situ encapsulation of GO-SNX with HA-based hydrogel. Results of in vitro testing indicate high loading of SNX onto GO, and subsequent slow release of SNX within therapeutic window. The slow release of SNX strongly relates to loading-ratio of GO to SNX. This strategy can also be applied in a variety of drugs in a similar manner, therefore offering a novel formulation for localized drug delivery applications.

Controlled release perivascular drug delivery from graphene oxide-hybridized HA hydrogels

254th National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.