Nitric oxide (NO) is a key mediator of human physiology including processes such as neurotransmission, blood pressure, and the immune response to pathogens.  The latter in particular, has led to much research on using NO as an alternative to traditional antibiotics. We have previously published on the synthesis of macromolecular NO-releasing nanoparticles as novel antibacterial agents. These systems allow for tremendous flexibility in the controlled release of NO. Herein, we describe the synthesis NO-releasing hyperbranched polyaminoglycosides, with comparison of NO release and other properties (e.g., stability, cytotoxicity) to previously published dendrimer systems. The antibacterial action of the hyperbranched polymers against both planktonic and biofilm based bacteria will also be described using Gram-positive and negative pathogens common to infection, as a full demonstration of the potential therapeutic utility of these materials.

Nitric oxide-releasing hyperbranched polyaminoglycosides as novel antibacterial agents

254th National Meeting (2017)

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