Previously, our lab developed a reaction generating a-halomethyl Ketones from terminal alkynes catalyzed by Au(III) catalyst in the presence of NXS. The a-halomethyl Ketones play an important role in synthesizing heterocyclic compounds called Indolizines. Indolizines are important biological compounds due to their antibacterial, antifungal, antiviral and antitumor activities. This one-pot synthesis of Indolizines is transition-metal free, utilizing an electron-deficient alkene and TEMPO as an oxidant[ii]. We present antibacterial activity of our Indolizine analogs on gram negative and positive bacteria, which included Escherichia. Coli, Staphylococcus Epidermis, Sarcina Marcescens, Micrococcus Luteus, Bacillus Cereus, Pseudomonas Aeruginosa and Proteus Vulgaris. A spread plate method was used to determine antibacterial activity with agar growth nutrient medium. Formalin 1% was the established positive control and DMSO as the negative control. Preliminary results showed some inhibition of selected bacteria, using 50 mL from 2 mg/mL stock solution of Indolizine analogs. Further investigation is currently being conducted to establish proper antibacterial activity of our Indolizine compounds.

Synthesis of heterocyclic indolizines and its antibacterial activity study

254th National Meeting (2017)

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