Transition metal catalyzed C–H oxidation reactions are important in the functionalization of pharmaceuticals and agrochemicals. These reactions require a stoichiometric, sometimes even super-stoichiometric, amounts of strong chemical oxidants. Electrochemical oxidation is an attractive, potentially much milder alternative. This presentation will demonstrate the realization of a mild palladium electrocatalyzed oxidation of alkane and arene substrates. Diverse C–H functionalization products containing oxygen nucleophile are obtained. Reaction optimization has been conducted, guided by mechanistic considerations.

Electrochemical approach towards palladium-catalyzed C-H oxidation

254th National Meeting (2017)

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