Heterocyclic compounds are an important class of chemical compounds that possess wide range of pharmaceutical and biological activities; thus play vital role in medicine, industry and life. Recent advance in the field of synthetic organic chemistry has brought into light many advanced techniques, such as transition metal-catalysed C-H activation, cross coupling reactions, multicomponent reactions etc., which have expanded the horizons in the field of heterocycles, a feat that was never envisaged before. Recently, we have reported synthesis and mechanistic insights of 2-aminobenzothiazoles from N-phenyl thioureas by ruthenium catalysed C-H functionalization/ C-S bond formation (Scheme1A). In continuation, we are exploring synthesis of bis-heterocycles from N-phenyl-2-aminobenzothiazoles by ruthenium catalysed C-H functionalization/ C-N bond formation via oxidative annulation (Scheme1B). Salient features and mechanistic aspects will be presented.

Exploration of advance synthetic processes for generating heterocyclic scaffolds: Synthetic scope and mechanistic insight

254th National Meeting (2017)

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