Current methodologies of photolabile triggered degradation of materials rely on light outside the tissue-penetrant light window to release encapsulated guests. Therefore, material platforms that can harness this biologically compatible red and near-IR light for degradation-release and delivery of guests is an active area of study. Two-photon absorbing moieties harness the low energy of tissue penetrant light to cleave bonds otherwise normally broken in the UV range. Combining red and near-IR light absorbing moieties as crosslinkers in polymeric nanogels loaded with fluorescent guests allows for photo-triggered dissolution and guest delivery as a model for therapeutics release.

Light driven degradation of nanogels and triggered release of guests

254th National Meeting (2017)

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