Limited research is currently available on the stability of biomedical grade materials under radiation in aqueous conditions. However, some studies suggest medical devices can fail with prolonged exposed to radiation in an <i>in vivo </i>environment. As the number of implanted devices and exposure to radiological exams/radiotherapy increases it is essential that implanted materials are fully investigated at varying doses and dose rates. This study investigated two materials, polyurethane and silicone, under low doses of radiation (0-80Gy) and varying aged gamma sources (0.1 – 21yrs at 25kGy). Early results indicate at low radiation doses both polyurethane and silicone maintain chemical and basic thermal stability while altering early cellular responses. At higher doses (80Gy), cell count is significantly higher than other doses, suggesting material surface changes are influencing cells. This data provides valuable insight into initial reactions between ionizing radiation at low doses and biomedical grade polyurethane and silicone.

Investigation into the stability of biomedical grade polyurethane and silicone exposed to ionizing radiation at low doses

254th National Meeting (2017)

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