The focus of this research project is to develop novel, bio-hybrid electrodes for lithium ion batteries which demonstrate improved performance parameters compared with existing materials. The proposed research goal may be classified into three specific aims: 1) Identification and Characterization of Solid Binding Peptides for Lithium Ion Battery Electrode Materials 2) Bio-tethered Electrodes for Improvement of Cycle Life, Energy Density, and Power Performance and 3) Biomimetic Synthesis of Electroactive Particles Utilizing Identified Solid Binding Peptides.<br/>Currently, research is significantly focused on identifying and characterizing peptides with specific inorganic material binding affinities. Initially, the use of a combinatorial phage library enables bio-panning experiments to be performed for the isolation of mutant phage, which exhibit a binding affinity toward materials of interest such as LTO, Stainless Steel, and Multi-walled Carbon Nanotubes. Output/Input assays initially compare the binding affinities of various identified mutant phages. The peptides expressed by the binding mutant phage will then be purchased, or expressed and purified from bacteria, to study the individual peptides of interest. Isothermal Titration Calorimetry, site-directed mutagenesis, and Nuclear Magnetic Resonance (NMR) experiments are further utilized to identify specific amino acids residues required for material binding and to identify quantitative dissociation constant values for these peptides.

Identification and characterization of novel peptide domains, which exhibit binding affinities for electroactive materials

254th National Meeting (2017)

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