Some amyloid-related proteins/peptides are involved in aggregation and pore formation in phospholipid membranes (cell membranes), and result in a variety of neurological disorders such as Alzheimer disease (AD), Parkinson disease (PD), Huntington disease etc. In this research, we investigate the mechanism of pore formation by amyloid β peptides using molecular dynamics (MD) simulation, to simulate amyloid β peptide interaction with lipid membrane and evaluate the potential energy of interaction. 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) membrane system with different cholesterol concentration was used in this research to simulate mammalian cell membrane. The results indicated amyloid β peptides oligomers with peptide number larger than two would lead to lipid deformation, and the free energy of penetration into membrane decreased with increasing number of peptides. Increasing concentration of cholesterol prevents the penetration of peptides. The results of this research have potential application on prevention of pore formation on lipid membrane by aggregation of amyloid β peptides.<br/>

Interaction of amyloid β peptides with lipid membrane

254th National Meeting (2017)

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