<br/>Polylactide (PL) is an aliphatic polyester that can be obtained from renewable resources. It is both biocompatible and biodegradable. Medical devices made out of PL have been approved by FDA for use in humans. However, a major limitation of PL is the lack of reactive functional groups appended along the backbone. We have synthesized a variety of copolymers of PL that bear functional groups, including azido, chloro, thiol and bromo substituents, along with an analog that contains α,β-unsaturated esters. The presence of functional groups will enhance the utility of PL by virtue of the ability to attach peptides, proteins and drug molecules. We demonstrate the utility of these copolymers for a variety of biomedical applications.

New functional polylactides for biomedical applications

254th National Meeting (2017)

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