Metallofoldamers having polymeric frameworks can be used as synthetic mimics of metalloenzymes to catalyze analogous biological reactions. However, the role of polymer frameworks on the reaction activity and selectivity of metallofoldamers is currently not clear. In this talk, I will present our recent focus on the metal-containing single-chain polymeric nanoparticles (SCPNs) and show how polymer frameworks influence the catalytic activity of metal sites. Two examples will be discussed, including i) the design of copper-containing SCPNs for hydroxylation reactions; and ii) nickel sulfides-containing SCPNs for photocatalytic CO<sub>2</sub> reduction. Metal-containing SCPNs consisting of folded polymers incorporated with metal complexes are prepared via intramolecular metal-ligand coordination with functionalized linear copolymers. The folded polymer backbone resembles the protein framework to provide a second coordination sphere to active sites. We will show how the chemical functionality and dynamics of polymeric frameworks modulate the coordination of metal sites and the catalytic activity/selectivity.

Folded polymeric frameworks to promote reaction activity and selectivity of metal and metal clusters

254th National Meeting (2017)

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