Only a single patient has been cured of HIV infection despite the availability of extremely effective antiretroviral drugs.  This talk will discuss the unexpected finding that some antiviral drugs have highly cooperative dose response curves that allow near complete inhibition of viral replication.  The cure of hepatitis C infection will be discussed in this context.  The reason that HIV infection cannot be similarly cured is a small reservoir of resting memory CD4+ T cells harboring a latent, non-replicating form of the virus.  The challenges involved in the ongoing search for small molecules that target this latent reservoir will be described.

Curing HIV infection: Going beyond N = 1

254th National Meeting (2017)

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