In recent years, the interest in nanoscale materials for teragnostic applications, for instance against cancer, has increased. The present work has been focused on the synthesis and study of multifunctional hybrid nanostructures, composed of inorganic nanoparticles (NPs) and nanoscale metal-organic-frameworks (MOFs). Thus, hybrid materials with properties derived from inorganic NPs and large/versatile encapsulation properties were produced. The hybrid nanostructures were synthesized by growing ZIF-8 (Zeolitic Imidazolate Framework based on Zn<sup>2+</sup>) around pre-stabilized NPs. UV-Vis spectroscopy, X-ray diffraction and dynamic laser-light scattering (DLS) were performed in order to characterize the physicochemical properties of the composites. Aditionally, the composites morphology was characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Encapsulation and release of several antitumoral drugs was also investigated.

Hybrid nanocomposites based on nanoMOFs and nanoparticles for theragnostic applications

254th National Meeting (2017)

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