Implantable glucose biosensors have been commercialized with the goal of helping diabetics better manage their disease. Unfortunately, such devices are currently only approved for use up to 7 days due to significant loss of sensitivity caused by a host-mounted foreign body response (FBR). Nitric oxide (NO) is an endogenous species with important roles in regulating the inflammatory response and angiogenesis, which may mitigate the FBR associated with sensor implantation. Preliminary results suggest low levels of NO release actually improve sensor performance. In order to better understand the importance of NO-release duration on sensor performance, we have designed a long duration NO-releasing sensor coating. Nitric oxide-releasing mesoporous silica nanoparticles were prepared with thermally-labile S-nitrosothiol (RSNO) NO donors capable of releasing NO under physiological conditions. Due to the increased surface area of the mesoporous scaffold, large NO totals (&gt;3 µmol/mg) were achieved with this system. More notably, the NO-release duration of the particles (&gt;13 days) provides a system capable of extended NO-release. Subsequently, RSNO-functionalized particles were encapsulated in several polyurethanes that mimic functional glucose sensor membranes. In such membranes, the NO-release was extended to greater than 30 days with &lt;1% leaching, independent of polyurethane hydrophobicity. This presentation will also describe the influence of the particles on sensor performance.

S-Nitrosothiol functionalized mesoporous silica nanoparticles for extended nitric oxide-release

254th National Meeting (2017)

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