The sensitive and selective detection of organochlorine pesticides in contaminated biological systems remains a high priority due to the pesticides’ toxicity and carcinogenicity. The detection reported herein is facilitated by cyclodextrin, which acts to promote proximity-induced fluorescence modulation of three high quantum yield fluorophores when in close proximity to the pesticide, creating measurable, analyte-specific changes in the fluorescence emission. This method was tested at various temperatures and concentrations, and resulted in 100% success in differentiating between structurally similar organochlorine pesticides. The high selectivity of this method has significant potential in the development of new, practical detection devices for pesticides in complex biological and marine environments.

Detection of organochlorine pesticides in contaminated biological systems via cyclodextrin-promoted fluorescence modulation

254th National Meeting (2017)

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