Widely recognized as one of the premier functional genomics research tools, RNA interference (RNAi) has been used extensively to assign functions for genes annotated through small (expressed sequencing tags) or large (whole genome) scale sequencing efforts. The agricultural industry has recognized the potential to utilize RNAi as a mechanism to control the expression of target genes for pest species such as the western corn rootworm. Efficient delivery mechanisms, RNA stability, and RNA toxicity to the target organism remain as major technical challenges. However, a number of different approaches are being developed to overcome these challenges including transgenic crop plants that express RNAi traits (in planta RNAi). RNAi-based rootworm management technologies are currently in development and are likely to become an important management tool that complements existing control practices including synthetic pesticides and Bt traits. This is especially important for the western corn rootworm, where Bt traits are being challenged by resistance evolution. However, it is critical that the technology is used in a manner that is both sustainable and environmentally safe. The lack of a formalized/standardized risk assessment (ERA) procedure remains as a regulatory obstacle to integrate RNAi management approaches into sustainable pest management practices.

Developing RNA interference as a pest management tool for western corn rootworm: Identifying opportunities and potential risks

254th National Meeting (2017)

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