DNA-encoded libraries (DELs) represent an up-and-coming strategy for significantly enhancing compound collections used for screening and ligand identification against therapeutic targets of interest. GlaxoSmithKline (GSK) has established DNA-Encoded Library Technology (ELT) as a platform that utilizes this strategy to identify small molecules for both target validation and medicinal chemistry progression.   A primary factor for the success of the technique is the chemical diversity of the libraries. This presentation will review the evolution of the platform over the past 12 years within GSK and the technical advances in library chemistry which enable the expansion of diversity and novel chemical space of the DEL collection.

DNA-encoded library technology (ELT): Challenges and advances in chemistry and library development

254th National Meeting (2017)

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