The ability to characterize the detailed physicochemical properties of individual nanoparticles is critical as nanomaterials expand their footprint within the global economy, particularly the behavior of nanomaterials in biological systems,. Improved nanoanalytical methods are needed to understand the nanoparticle properties, as well as the presence of impact of the protein corona. Silver nanoparticles are one of the most widely used engineered nanomaterials, but questions still remain regarding dissolution, agglomeration, and morphological changes after oral exposure in the gastrointestinal tract. Nanoparticle properties were probed during passage through a three vessel system representing the stomach, duodenum, and jejunum. Particles were sized with high time-resolution (30 second) nanoparticle tracking analysis (NTA) then probed with surface enhanced Raman spectroscopy (SERS) and electrospray ionization (ESI) coupled with dual-polarity single particle mass spectrometry. These instrumental approaches provides new methodologies to apply to future studies of nanotechnology, nanotherapeutics, natural exposure to incidental nanoparticles, or nanoparticles in food.

Detailed physicochemical characterization of individual nanoparticles with global implications through electrospray ionization coupled to real-time dual-polarity single particle mass spectrometry and surface enhanced Raman spectroscopy

254th National Meeting (2017)

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