The inhibition of acetyl-CoA carboxylase (ACCase) is one of the most commercially important modes of action for the control of grass weeds in cereals, rice and broadleaf crops. Three chemical classes of ACCase herbicides have been commercialized – FOPs (aryloxyphenoxypropionates), DIMs (cyclohexanedione oximes) and most recently DENs (2-aryl-1,3-diones). This presentation describes the discovery of a totally new class of ACCase herbicide with unprecedented levels of maize selectivity and weed control. Various aspects of chemical design and biology will be discussed, and the development of novel synthetic methodology will be presented.

Discovery of novel maize selective acetyl-CoA carboxylase inhibitors

254th National Meeting (2017)

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