The structure of the cell membrane can be affected by drug molecules and in turn can affect the pharmacological properties of the drugs being administered. In this study, using a Droplet Interface Bilayer as a model biomembrane, the effects of various common drugs, such as Caffeine and Acetaminophen, have been investigated to determine the physicochemical properties of several model monoglycerides lipid bilayers. The water permeability and activation energy of water transport across the monoglyceride lipid membrane have been studied in the presence and absence of drug molecule. We believe this study will contribute to broadening our understanding of molecular interactions of drugs with biological membranes.

Membrane–drug interactions: Effect on water permeability

254th National Meeting (2017)

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