A nickel-catalyzed cross-electrophile coupling reaction to synthesize cyclopropanes has been developed. This transformation proceeds with fluorinated starting materials, despite the usual lack of reactivity of the C–F bond. A variety of aryl and alkyl-substituted substrates are tolerated in the cross-electrophile coupling reaction, and substituted cyclopropanes are formed with high diastereoselectivity.

Nickel-catalyzed reductive cross-electrophile coupling reactions of alkyl fluorides for cyclopropane synthesis

254th National Meeting (2017)

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