We have found that cyclic amide isosteres of cyclic imines often retain the biological activity present in the original structure. Recently 3-aryl-isoxazoline-5-carboxamides have demonstrated interesting levels of post- and preemergence herbicidal activity in a series of patent applications from Bayer CropScience. Oxazolidinone cyclic amide isosteres of these isoxazolines are easily synthetically accessible from glycidic esters and substituted anilines in a short sequence. These oxazolidinones have good levels of herbicidal activity and control the most sensitive weeds at rates of 32 g/Ha and lower. This presentation will focus on the synthesis, structure-activity relationships, and biological activity of these compounds.

Herbicidal oxazolidinones

254th National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.