The druggable genome corresponds to the set of protein targets that are amenable to small molecule perturbation. While this set of targets has enormous potential in terms of understanding and treating many disease conditions, the bulk of them are understudied or not studied at all. To address this the NIH initiated the "Illuminating the Druggable Genome" program to characterize the dark regions of the druggable genome. As part of this program, a Knowledge Management Center (KMC) was created to aggregate and integrate heterogeneous data sources and data types creating a centralized location for information about all protein targets identified as part of the druggable genome. In this presentation, we describe the design and deployment of Pharos, the user interface for the KMC. We provide an overview of the data sources and types made available via Pharos and then describe the architecture of the system and its integration with KMC & external resources. Given the heterogeneous set of data types available for individual targets, it is useful to quantify how much and what types of data is available for a target. We describe the development of knowledge profiles and a Knowledge Availability Score (KAS), both derived from the Harmonizome, which is a resource that has characterized data availability across different data sources and types in a uniform manner. We then highlight how the KAS is concordant with knowledge trends characterized by traditional metrics such as publications and grants.  We discuss the use of the KAS in the Pharos interface and an example of prioritizing understudied targets by computing the similarity of their knowledge availability profiles with that of well-studied targets

Pharos: Putting targets in context

254th National Meeting (2017)

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