We seek to create foldamers of peptidomimetics with well-defined three-dimensional structure and function. In nature, the tertiary structure of proteins is partially developed through specific interactions within secondary structural elements such as helices. Peptidomimetics especially N-substituted glycine oligomers (or peptoids) provides an avenue to rationally design and develop structurally well-defined foldamers. Our research focuses on understanding the structural requirements in designing helical coils of short-lengths of peptoids, and a means to induce sequence-specific interactions within these structures. Design, synthesis and helical peptoid block association will be discussed.

Minifoldamers: Design, synthesis and study of specific interactions in peptoid helices

254th National Meeting (2017)

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