Reductive cross-electrophile couplings are versatile reactions for the formation of sp2-sp3 bonds between aryl and alkyl halides without the need for pre-formed organometallic reagents. While powerful, these reactions can be limited by the use of multiple equivalents of a metal powder to reduce the nickel catalyst, which can lead to inconsistencies in yield and conversion from the degree of metal activation as well as problems with substrate compatibility. This talk explores the use of electrochemistry as a potentially milder and more consistent method for driving Ni-catalyzed sp2-sp3 cross-couplings.

Electrochemical methods for Ni-catalyzed sp2-sp3 cross-couplings

254th National Meeting (2017)

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