This presentation will contain a summary of recent developments in the use of two catalyst systems for the asymmetric reduction of ketones; i) the class of Ru(II) complexes containing a diamine attached via a 'tether' to an aromatic ring of general structure <b>1</b>, and ii) ironcyclopentadienone tricarbonyl complexes of general structure <b>2</b>. In the case of the Ru(II) catalysts, a diverse range of applications will be described in which high enantioselectivities have been achieved, including those illustrated in Figure 1. The iron complexes have demonstrated excellent abilities as catalysts for transfer hydrogenation reactions including 'hydrogen borrowing' and are being developed as asymmetric reagents. Figure 2 illustrates a general application and the proposed transtion state for hydrogen transfer reactions.

Asymmetric catalysis of ketone reduction using ruthenium and iron-based catalysts

254th National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.