Macromolecular architectures play a pivotal role in nanomedicine, as they allow for accurate tuning of physicochemical properties and surface functionality. Moreover, these nanostructures are readily accessible through controlled radical polymerization techniques. Degradability of the nanostructures is an important issue that still has received only limited attention. Little is known about the fate of nanostructures in the human body, though preventing unwanted side effects is of utmost importance.<br/><br/>We set out to develop a platform technology that enables endowing vinyl polymers and their resulting macromolecular architectures with degradability and responsiveness. Radical ring opening polymerization of cyclic allyl sulfides is incorporated in existing approaches towards micro- and nanostructures to render the resulting materials responsive and/or degradable. We will present here our results on reducible polymer nanoparticles, prepared via controlled crosslinking polymerization, in gene delivery.

Main-chain degradable polymer nanoparticles as gene delivery vectors

254th National Meeting (2017)

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