Our research is on the interface of macromolecular self-assembly and glyco-science. Recently, we developed a new strategy to construct protein assemblies by using carbohydrate interactions and p-p stacking. 3D protein crystalline frameworks and microtubules were obtained. Meanwhile, we first utilized the deprotection chemistry of carbohdyrate to induce to assembly of glycopolymers. By using different protect groups with different deprotection ratio, the kinetics of assembly was controlled. These assembled nanomaterials were utilized to polarize macrophages, especially tumor associated macrophages, which might be useful in cancer immunotherapy.

Macromolecular self-assembly from carbohydrates

254th National Meeting (2017)

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