A novel polymeric analogue of DMSO, poly(2-(methylsulfinyl)ethyl acrylate) (polyMSEA), was prepared by atom transfer radical polymerization (ATRP). Well-defined linear polymers were synthesized using low amounts of copper catalyst (100 ppm). Two types of star polymers were synthesized by either an "arm-first" approach or a “core-first” approach using a biodegradable beta-cyclodextrin core . The polymer showed high hydrophilicity and water solubility. The lower critical solution temperature (LCST) of poly(MSEA) was estimated to be ca. 140 °C by extrapolating the LCST of a series of copolymers with N-isopropylacrylamide (NIPAM). Both the linear polymer and star polymer showed low cytotoxicity, at concentrations up to 3 mg/mL.

New type of biocompatible polymer: Polymeric analogue of DMSO

254th National Meeting (2017)

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