Fluorescent probes have been extremely useful in elucidating biochemical mechanisms and processes inside of living cells via fluorescent microscopy. Fluorescent sensors are also being employed in medical diagnostics as a simple and convenient method to quantify important analytes in serum, for example. It is well known that many lipids and lipid-containing compounds possess significant biological activity, most of which are found in cellular membranes. Amphiphilic receptors are described which interact with both the head-group and the hydrophobic portion of the lipid. The amphiphilic nature of the sensor allows them to not only detect the lipids, but also extract them from a membrane. Studies with vesicles are used to demonstrate lipid extraction.

Fluorescent sensors for lipids

254th National Meeting (2017)

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