Herein we report a unique condensation/cyclization between α-oxoesters and cyclic imines to yield the highly versatile <i>3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones</i>. These transformations can be carried out on gram-scale and under mild reaction conditions. Biologically relevant molecules such as natural products, β-amino acids and β-lactams can be accessed in 2-3 steps from these functionalized cores and these efforts will be discussed.

Direct access to highly functionalized heterocycles through the condensation of cyclic imines and α-oxoesters

254th National Meeting (2017)

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