The melokhanines are a family of pentacyclic natural products isolated in 2016 from the Chinese plant Melodinus khasianus. Displaying potent antimicrobial properties against Pseudomonas aeruginosa, Escherichia coli, and Enterococcus faecalis, the melokhanines represent a promising target for total synthesis. Development of a facile route to the synthesis of the melokhanine family and the development of a small designed library of analogs will facilitate the development of the melokhanines into novel infectious disease lead compounds.

Total synthesis and SAR studies of the melokhanine family of natural products

254th National Meeting (2017)

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