Tricarbonylrhenium(I) polypyridyl complexes have been found to be highly cytotoxic on numerous cancer cell lines including U-937 lymphoma, MCF-7A and MDA-MB-231 breast, PC-3 prostate and BxPC-3 pancreatic cancer cell lines. Majority of the cancer drugs bind to DNA either directly or indirectly. We have synthesized a series of tricarbonylrhenium(I)-polypyridyl picolinato, nicotinato, and tryptophanato complexes. Several of these complexes are highly potent agianst breast cancer cell lines. The IC-50 values are less than 1 μM. The UV titrations of these complexes with DNA suggest intercalation as the preferred mode of binding. We would like to present our findings on the mode of action using other techniques such as viscosity, cyclic voltammetry, etc.

DNA binding studies of organorhenium picolinato, nicotinato, and tryptophanato complexes

254th National Meeting (2017)

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