Streptococcus agalactiae (Group B Streptococcus, GBS) is a Gram-positive bacterial pathogen that is a common cause of neonatal sepsis and meningitis. It has recently been proposed that breastfeeding represents a potential mode of GBS transmission from mother to newborn, which may increase the risk for late-onset sepsis. Little is known, however, about what molecular components of breast milk may support or prevent GBS colonization. Specifically, the effect of human milk oligosaccharides (HMOs) on GBS is of interest, as HMOs are known for their immunogenic properties. We have found that HMOs exert antimicrobial and anti-biofilm activities against GBS and have provided the first example of carbohydrates functioning as anti-biofilm agents. To study this phenomenon further, RNA-sequencing and proteomics experiments have been performed. Additional studies will investigate the effects of individual HMOs on GBS and may uncover unique structural motifs responsible for HMO antimicrobial and anti-biofilm properties.

Human milk oligosaccharides exhibit antimicrobial and anti-biofilm properties against Group B Streptococcus

254th National Meeting (2017)

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