Metal-catalyzed asymmetric synthesis of P-stereogenic phosphines is a potentially useful route to this class of valuable ligands. Most of the reported examples use precious metals, such as Pt, Pd, and Ru. To develop cheaper, more sustainable processes, we are investigating copper catalysts supported by chiral N-heterocyclic carbenes (NHCs). This presentation will cover the synthesis of chiral NHC ligands, preparation of Cu(NHC*) catalyst precursors, and applications in synthesis of P-stereogenic phosphines.

Toward copper-catalyzed asymmetric P-C bond formation using chiral NHCs

254th National Meeting (2017)

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