Low molecular weight Amphiphiles are commonly used as 3D carriers for cells because their properties can be tailored to match natural extracellular matrix. These Amphiphiles (Nanocarrier) may be used in tissue engineering and regenerative medicine to deliver therapeutic cells to injured or diseased tissue through controlled degradation. In this context, these carriers can act as “Shield” and hide biomacromolecules to prevent them from interacting with other species until desired. Hydrolysis and enzymolysis are the two most common mechanisms employed for Nanocarrier degradation, but neither allows sequential or staged release of cells. In contrast, photodegradation allows external real-time spatial and temporal control over degradation, and allows for staged and sequential release of Drugs/DNA. We have synthesized and characterized a series of Amphiphiles incorporating o-Nitrobenzyl groups which on photolysis triggers a structural disruption and the entrapped biomacromolecules are released into the bulk solution, where their bioactivity is recovered.

Development of photodegradable nanoarchitectures for drug/DNA loading and release

254th National Meeting (2017)

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