The high affinity folate receptor (FR) is overexpressed on approximately 80% of all cancer types and activated macrophages associated with numerous inflammatory conditions. Consequently, FR has emerged as an attractive target for the selective delivery of folate guided therapeutic agents and for development of diagnostic strategies that are able to identify folate receptor positive cancer and immune cells in both in vitro and in vivo assays. This report describes a rapid method for the construction of folate fluorophore surface labeled magnetic beads that can be used for capture and detection of FR+ cells. Conjugation to magnetic beads was achieved in as little as one minute after incubation of the beads with the folate fluorophore ligand. This strategy should prove useful for other targeting ligands and surface labeling schemes.  <br/>

Facile method for construction of folate targeted fluorescent magnetic beads

254th National Meeting (2017)

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