Hydrogen sulfide (H2S) and related reactive sulfur species are now recognized to play important roles in biology, health, and disease. Aligned with this increased interest, chemical tools that enable H2S delivery have emerged as important research tools with high pharmacological potential. To expand the available chemical toolbox of H2S-releasing molecules, we recently demonstrated that caged thiocarbamates can be used to access triggered H2S donors. These systems function by the intermediate release of carbonyl sulfide (COS), which is quickly converted to H2S by the ubiquitous enzyme carbonic anhydrase. This presentation will focus on (1) recent work from our lab aimed at diversifying available COS/H2S donor core motifs; and (2) the synthesis, characterization, and application of new COS donors activated by specific stimuli, including biologically-relevant small molecules, bio-orthogonal triggers, and enzymatic reactions.

Chemical tools for carbonyl sulfide (COS) and hydrogen sulfide (H2S) delivery

254th National Meeting (2017)

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