Colloidal superparamagnetic iron oxide nanoparticles (SNPs) have been extensively explored for various biomedical applications. In particular, successful in vivo MRI applications require control over surface chemistry of SNPs. During blood circulation, poor colloidal stability of SNPs in the presence of serum proteins could result in the occurrence of undesired aggregation, leading to decrease in their magnetic and MRI properties. Consequently, the design of optimal single coating layer on SNP surfaces is essential for enhanced magnetic properties and prolonged colloidal stability in biological environments. Furthermore, the choice of anchoring groups on SNP surfaces is important to facilitate stabilizing ligands being effectively bound to SNP surfaces. Our group has studied a multidentate block copolymer (MDBC) strategy to stabilize SNPs. We have synthesized well-defined MDBCs having pendant carboxylates and catechol groups as multidentate anchoring groups bound to nanoparticle surfaces. This coating yields small nanoparticles (hydrodynamic size &lt;20 nm) with excellent colloidal stability under physiological conditions as well as magnetic resonance imaging contract enhancement in vitro and in vivo (animal models).

Multidentate block copolymer strategy to fabricate aqueous colloids of iron oxide nanoparticles for magnetic resonance imaging contrast enhancement

254th National Meeting (2017)

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